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Colts vs. 49ers prediction, odds, start time: 'Monday Night Football' picks, best bets from proven model

Dec 21, 2025 - 19:45
Colts vs. 49ers prediction, odds, start time: 'Monday Night Football' picks, best bets from proven model
The SportsLine projection model has revealed its Indianapolis Colts vs. San Francisco 49ers picks for the 2025 NFL Week 16 'Monday Night Football' game
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